How to Inject Testosterone: Where Each Product Goes and What to Confirm First
How to inject testosterone depends on the exact product in your hand. The listed products for muscle injection are labeled for the buttock; Xyosted goes under the belly skin only. Aveed requires a certified healthcare setting and 30 minutes of observation. Match your product below, and confirm any label-versus-prescription difference with your care team.
For prescription holders: find your product instructions here; get injection training from your care team. Urgent symptoms? See when to get medical help.
Testosterone injection sites by product: where does yours go?
Where you inject testosterone depends on the exact product and device. The cypionate and enanthate vial labels we checked specify deep injection into the buttock (gluteal) muscle, Xyosted is labeled for under the skin of the belly, and Aveed and both Azmiro presentations are given by a healthcare professional. If your prescription says something different, ask your prescriber to explain the difference.
Two quick definitions before the table:
- IM (intramuscular) means the medicine goes into a muscle.
- SubQ (subcutaneous) means it goes into the fat just under the skin.
Find your product's name on the box or vial label. Then find its row.
Compiled by TRT Provider Guide from U.S. prescribing information, checked October 29, 2026. Label revision dates: Depo-Testosterone September 2025; Hikma cypionate and enanthate June 2025; Xyosted, Azmiro and Aveed July 2025. This table describes labels. It does not choose a site for you or confirm your prescription.
This page is for you if: you have a testosterone prescription (or are about to), and you want to be sure you're injecting the right product, in the right area, the way your care team intended.
This page is not for you if: you don't have a prescription, or you're looking at testosterone for bodybuilding or performance. Testosterone is a controlled substance that requires a prescription, and we don't cover nonmedical use. If you're still deciding whether TRT is right for you, start here instead.
Educational information, not medical advice. This guide doesn't confirm your prescription or replace injection training from your care team. If you have trouble breathing, swelling of your lips, mouth or face, or chest pain after an injection, call 911. A newly painful, swollen, warm or red leg needs prompt medical assessment.
Compounded testosterone: a separate preparation
The FDA explains why compounded preparations are not FDA-approved.
That's the short answer. Here's the key point: the body diagram you're looking at may not match the medicine you were prescribed. A vial, a prefilled syringe and an autoinjector pen can contain the same kind of testosterone and still come with different rules about where it goes and who gives it.
So we did the matching for you. The table covers the U.S. injectable products and specific generic packages we checked, what their official labels say, and where to open their instructions. You'll also find a ready-to-send message for when your vial and your prescription don't agree, plus clear signs that mean "call someone now."
Three things in that table trip people up:
- "Prefilled" doesn't mean "for home use." Azmiro's prefilled syringe is a glass syringe with no needle in the box, and its label says a healthcare professional gives it. It's not a self-use pen like Xyosted.
- Same ingredient, different rules. A generic enanthate vial and the Xyosted pen both contain testosterone enanthate. One is labeled for muscle. The other is labeled for under the belly skin. A Xyosted video won't teach you how to use a vial.
- Generic packages vary. We checked one Hikma cypionate vial and one Hikma enanthate vial. If your box shows a different manufacturer or NDC number (the National Drug Code identifying the package), ask your pharmacist for the label that matches it. Don't match by ingredient alone.
What if your product isn't listed, or you can't tell what it is?
TRT Provider Guide is the independent decision resource for testosterone replacement therapy — helping U.S. adults understand how low testosterone is evaluated, compare online and local care models and providers, and choose the next step that fits their health needs, fertility plans, budget, state, and care preferences, with every material claim verified and dated.
Don't have a prescription yet?
The right TRT provider is not the same for every person — it depends on whether low testosterone has been properly evaluated, your symptoms and health history, your fertility plans, your state, your insurance or cash-pay preference, your treatment-format preference, your budget, and whether online or in-person care is the better starting point. Some situations belong with primary care, urology, endocrinology, reproductive urology, or urgent or emergency care when the symptoms warrant it. Because a general answer cannot resolve those for you, discuss the right care route with a clinician. If you are exploring online TRT programs, use TRT Provider Guide's Find My TRT Path tool to explore those options.
Use Find My TRT Path → Free and educational. It doesn't diagnose low testosterone or guarantee a prescription.
Why does my vial say IM when my prescriber said SubQ?
Your prescriber may have chosen an off-label use, which means using an FDA-approved drug in a way its label doesn't describe, such as injecting an IM-labeled vial under the skin. The FDA says clinicians may do this when they judge it medically appropriate. A website can't confirm that the difference in your case is intentional, so ask your prescriber or pharmacist to confirm it in writing.
One person put it plainly in a TRT forum: the prescription said SubQ, but the bottle said intramuscular.
Here's what's going on. Every standard testosterone cypionate and enanthate vial we checked is labeled for muscle. But clinicians sometimes prescribe those same vials for under-the-skin use. A 2022 review in the Endocrine Society's journal found that, in the limited studies available, similar SubQ and IM doses produced comparable testosterone levels (Figueiredo et al., 2022). So the difference may be completely intentional.
It may also be a mix-up. Only your care team knows which.
Off-label isn't the same as compounded. Off-label means an approved drug used in a different way. Compounded means a pharmacy made the preparation itself, and the FDA says compounded drugs are not FDA-approved and aren't reviewed for safety, effectiveness or quality before they're sold. If your testosterone is compounded, there's no FDA-approved label for that preparation to compare against. Get its written directions from your prescriber and dispensing pharmacy.
Match your situation to the right question
Copy this message to your care team
Fill in the brackets and send it through your patient portal, or read it aloud at the pharmacy.
Please confirm my testosterone injection instructions.
My package says: [exact product name and manufacturer].
It's a: [vial / prefilled syringe / autoinjector pen / not sure].
The package says: [IM / SubQ / other wording / not sure].
My written plan says: [IM / SubQ / unclear].
Please confirm which instructions apply to this exact product, the injection site you want me to use, and who should give it. If my plan differs from the package label, please explain why in writing. Please also confirm my supplies, who will teach me, whether someone can watch a practice injection, how to store the medicine, and whom to contact if I miss an injection or something seems wrong.
That message can save you from guessing the next time your injection is due.
Can testosterone go in the thigh, shoulder, hip or belly?
Those areas aren't an interchangeable menu for every testosterone product. Xyosted is labeled only for the belly, the vial labels we checked name the buttock muscle, and other areas require product-specific instructions from your prescriber. Don't switch to a new body area from a general diagram; ask the person who trained you.
You've probably seen diagrams showing six or more "testosterone injection sites." Those diagrams may show common injection areas, but they can miss the most important column: which of those spots your product and your prescriber actually allow.
Sources: product labels above; MedlinePlus, "Giving an IM injection" (reviewed July 23, 2024); Xyosted Instructions for Use.
Here's a surprising finding about reaching the intended tissue. Imaging studies summarized in that 2022 Endocrine Society journal review estimated that 12% to 85% of intended IM injections in men were deposited under the skin (Figueiredo et al., 2022). These were general injection-placement studies, not a measured error rate for testosterone injections. That's exactly why the right needle and the right spot for your body should come from someone who has seen your body.
Is one site best or least painful? There's no universal winner. A small study in 14 transgender men found less reported pain with SubQ, but that doesn't tell us which method will hurt less for everyone, and the choice also changes which products fit. If you're weighing a switch, our full subcutaneous vs intramuscular testosterone comparison breaks down the evidence. Then talk to your prescriber before changing anything.
How can you learn how to inject testosterone safely?
Start with a hands-on lesson from your care team using the exact medicine and supplies you'll use at home, ideally with someone watching your first injection. Xyosted's label says not to inject until you've been trained, and Azmiro's prefilled syringe and Aveed are given by professionals. Written guides and videos help you review a lesson, but they can't check your technique.
Why we don't publish our own needle tutorial
You searched "how to inject testosterone," so this deserves a straight answer.
We don't publish needle angles, depths, needle sizes or landmark-finding steps. Not because it's secret. Because a website can't see your body, your product or your hands, and those three things decide the details. A spot that's right for a lean 5'8" man can be wrong for a 260-pound man. A technique that's right for a vial may be wrong for an autoinjector.
What we can do is point you to the official step-by-step instructions written for patients, and tell you exactly what your lesson should cover so nothing gets skipped.
Official step-by-step instructions written for patients:
- For IM injections in general: MedlinePlus, "Giving an IM (intramuscular) injection", from the U.S. National Library of Medicine. It covers supplies, site-finding for the thigh, hip, upper arm and buttock, the injection steps, needle disposal and when to call a doctor. Even MedlinePlus says to show your provider how you'll choose your spot.
- For Xyosted: the Instructions for Use inside the prescribing information, with pictures for each step.
- For everything else: the written instructions from your prescriber and your pharmacy label.
What your injection lesson should cover
Bring this list to your teaching visit or video call. If your lesson skips something, ask.
A practice run beats a perfect explanation. Ask whether a nurse or clinician can watch you do your first injection, in person or on a video call. Some online programs offer this. Hone Health says it will arrange a live tutorial on request, and Male Excel says its provider walks patients through dosing, SubQ technique and storage. Both are provider-stated, not something we tested. Both providers have commercial relationships with TRT Provider Guide; see our affiliate disclosure.
If you're scared of the needle
You're in good company. One person in a TRT forum asked, "Is anyone else scared of injecting themselves?" Another described being "very nervous about doing it wrong".
That fear is useful. It means you're taking it seriously. The next step isn't to push through it alone. It's to get shown again, slowly, and tell your care team if fear is stopping you. The patient video published by ECU Health says most people find self-injection gets easier after a few tries. Asking for a second lesson is normal. Nobody at a good clinic will think less of you.
What should you check before every testosterone injection?
For home injections your clinician has prescribed and taught you to give, confirm the exact product and expiration date, and follow its written instructions for equipment, hand and skin cleaning, and site rotation. Have a sharps container ready before you start. If anything about the product, device or directions has changed, ask your pharmacist before you inject.
Use this checklist alongside your product instructions and training:
- Right product, right strength. Read the label every time, especially after a refill. Pharmacies sometimes switch manufacturers.
- Not expired, and the liquid looks right. Xyosted's label says not to use it if the liquid is cloudy or has particles. Follow your own product's label for what it should look like.
- Single-use injection equipment. For a vial injection, use a new sterile needle and syringe each time. Do not reuse or share needles, syringes or single-use autoinjectors. The CDC is clear that needles and syringes are single-use.
- Clean hands. Wash with soap and water and dry them, as MedlinePlus describes.
- Clean, dry skin. Wipe the spot with alcohol and let it dry first.
- A new spot. Rotate. Keep a simple log of where you injected last.
- Sharps container within reach. You'll drop the used needle in right away, without recapping it.
Storage: follow your label. For example, Pfizer lists room temperature (68°F to 77°F) and protection from light for its testosterone cypionate. Don't assume another product follows the same rule, and don't use a "rule of thumb" from a forum for how long an opened vial lasts. Ask your pharmacist.
How much and how often? That's set by your prescriber and printed on your prescription. Never change it yourself. If you're curious why some plans are daily and others weekly, our daily vs weekly testosterone injections guide explains the tradeoffs.
What if an injection leaks, a device fails, or you miss a dose?
Don't guess and don't take an extra dose. Contact your prescriber or pharmacist and tell them what happened. For Xyosted, the official instructions say not to inject another dose if you're unsure the full dose was delivered, and to contact your healthcare provider or pharmacist promptly.
It's tempting to "make up" a leak or a missed day. Don't. You can't tell from a wet spot on your skin how much medicine you actually got, and neither can we.
- Some liquid leaked out: Note the date and what happened. Tell your care team. Don't re-inject on your own.
- The pen or device didn't seem to work: For Xyosted, check its Instructions for Use and call your provider or pharmacist. Don't use a second pen without their okay.
- You missed your planned day: Call or message your prescriber and follow their instructions. Don't double up.
A quick message beats a bad guess every time.
Is pain, a lump or bruising normal, and when is it an emergency?
Some soreness, a small bruise or a small lump can happen after an injection. Call 911 for a rash, severe itching, trouble breathing, swelling of your mouth, lips or face, chest pain, or sudden shortness of breath after an injection. A newly painful, swollen, warm or red leg needs prompt medical assessment; contact your care team if you get a fever, feel sick, or have a lump, bruise or swelling that doesn't go away.
How common are minor site reactions? In Xyosted's two clinical studies, 12.7% of 283 men had an injection-site reaction during treatment for up to one year, and none stopped treatment because of it (Xyosted prescribing information, section 6.1). That's one product's study result, not a way to judge whether your own reaction is harmless.
We won't tell you a lump is "normal" from a description, and we won't give you a number of days to wait. A photo on a website can't tell an oil bump from an infection. Your care team can.
How do you get rid of used testosterone needles?
Put used needles and syringes in a sharps container right after use, without putting the cap back on. Never throw loose needles in the trash or recycling, or flush them. When the container is about three-quarters full, follow your state or local rules to get rid of it.
The FDA recommends a simple two-step process:
- Right away: drop each used needle and syringe into a sharps container. MedlinePlus says not to put the cap back on first. Recapping is how people stick themselves.
- When it's about ¾ full: get rid of the whole container the way your community allows. Overfilling raises the risk of a needle stick.
Which container? An FDA-cleared sharps container from a pharmacy or online is best. If you can't get one, the FDA notes some communities allow a heavy-duty plastic household container, like a laundry detergent bottle, as an alternative.
Where does the full container go? That depends on your state. Some allow it in household trash when sealed. California bans that, but approved options include collection and mail-back programs. Look up your state's rules at SafeNeedleDisposal.org.
Traveling? The FDA suggests carrying a small travel-size sharps container.
What if you need a provider that teaches you how to inject?
If your current clinic just mailed you a vial with no real lesson, ask for a teaching visit before trying to work it out alone. If you need a different care team, compare who teaches you, which product they prescribe and who answers questions between visits. The table below records provider-stated offers; it does not establish which program fits your health needs.
Affiliate disclosure: TRT Provider Guide has commercial relationships with Male Excel, Taurus Meds and Hone Health and may earn a commission from some links. That doesn't change what we report, and we include options that don't pay us when they fit better. Read our affiliate disclosure.
First, two non-negotiables that apply to every option:
- You need a valid prescription. Testosterone is a Schedule III controlled substance in the U.S. and requires a valid prescription.
- Low testosterone should be properly confirmed first. For adult men being evaluated for testosterone deficiency, the Endocrine Society recommends compatible symptoms or signs plus clearly and consistently low testosterone, measured with accurate tests and confirmed by repeat morning, fasting testing. It also recommends against starting testosterone when planning fertility in the near term. These diagnostic criteria do not describe the evaluation for gender-affirming care.
What we actually verified
Checked October 29, 2026: Male Excel's TRT, injection, pricing and FAQ pages; Taurus Meds' $49 offer and subscription/refund terms; Hone Health's cost, membership and self-injection pages; the product labels above; the federal telemedicine rule.
Verified document facts: the checked FDA-approved products' labeled methods and administration restrictions; what each provider publishes about its offer; the conditional federal telemedicine extension through December 31, 2026.
Provider-stated, not independently confirmed: prices, supplies, injection training, schedules, cancellation terms and state coverage. We didn't enroll, inject anything, or inspect a dispensed vial.
Could not confirm: complete first-year checkout totals, the actual clinician and pharmacy assigned to a reader, individual state access, repeat-test inclusion across every plan, the exact preparation Taurus or Hone would dispense, or delivery of the promised teaching. Our method: How We Review TRT Providers.
How we did the math: Male Excel = $99 start + 12 × ($79 or $99) membership + 6 × $125 medication bills + 12 × $15 syringes. Taurus = $49 + 12 × $149. Hone = $65 + $25 + 12 × ($135 or $155) membership + 12 × $28 medication. These are calculations from published prices, not prescriptions, checkout totals or a ranking.
Why these aren't complete first-year costs: six 60-day medication supplies cover 360 days, not 365. Male Excel's shipping, actual refill billing dates, annual-plan payment terms and any extra required testing still need confirmation. Its separate pricing page also lists a different injection-and-thyroid bundle; don't mix the two offers. Taurus's ongoing lab and shipping costs are not itemized on the $49 offer. Hone's model assumes its lowest published medication cost applies every month and that the listed testing fees apply; its pages do not present the same membership choices. Confirm your exact product, quantity, required labs, teaching, shipping and billing schedule before paying.
Sources checked October 29, 2026: Male Excel injection offer, start and membership information, separate bundle prices; Taurus $49 offer; Hone cost article and membership page.
If you are considering daily SubQ injections: Male Excel
Male Excel describes daily injections, not a once-a-week plan. Its advertised plan is a small injection under the skin every day, which adds up to about 365 a year. If fewer shots is your top priority, ask your clinician about a different prescribed schedule or treatment format. Taurus advertises a weekly plan, and Xyosted is labeled for weekly use; neither is automatically the right fit for you.
Male Excel says its daily SubQ plan uses a fine needle and that its provider walks you through measuring your dose, technique and storage. That is a teaching promise to confirm, not evidence that this compounded program causes less pain or solves needle fear. Ask who gives the lesson, whether they can watch you practice, and how you get help afterward.
Before you decide, check fit:
- It's compounded. Male Excel's own page says its compounded medications aren't FDA-approved or evaluated by the FDA for safety, effectiveness or quality. If you want only an FDA-approved product, ask your own doctor about an approved vial product or Xyosted. A preference for a smaller needle does not establish a need for a compounded preparation.
- Not every state. In our October 29, 2026 check, Male Excel's FAQ listed 11 states where its providers don't prescribe hormone treatment: Alabama, Alaska, Arkansas, Connecticut, Hawaii, Idaho, Louisiana, Minnesota, Mississippi, New Hampshire and Rhode Island.
- Ask how your diagnosis is confirmed. Male Excel says its care is guided "by symptoms, not lab numbers alone." National guidelines call for symptoms plus consistently low lab results, so ask how they'll confirm yours.
- An in-person exam may be required. Male Excel notes that DEA and state laws may require one.
Does that sound like your situation? Read our Male Excel testosterone injections breakdown → Treatment requires a clinician's evaluation. Approval and a prescription are never guaranteed.
If you'd rather inject once a week: Taurus Meds or your own doctor
In our October 29, 2026 check, Taurus Meds' offer page described weekly intramuscular testosterone cypionate, a $49 blood test and consult, then $149 a month if approved. One caution: that page repeated the same "weekly intramuscular injections" line under products that aren't injections, so confirm your actual prescribed product and schedule before paying.
If you are comparing these programs after discussing your treatment plan, compare Male Excel and Taurus Meds side by side →
If you are considering Hone Health's vial program
Hone says its medication price includes the materials needed for injection, and that it sends separate needles for drawing medicine and for IM or SubQ use. It also says it will arrange a live tutorial if you ask. It doesn't take insurance. Its cost article lists a $135 Plus membership and a $155 Premium membership, while its membership page shows the $155 Premium option. Ask which plan you would actually join and whether the live lesson is included before paying.
If you want FDA-approved testosterone and insurance
Start with your own primary care doctor, urologist or endocrinologist. Ask about generic testosterone cypionate or enanthate used as labeled, or about Xyosted. Ask your nurse or pharmacist whether they can teach you the injection. Our guide to TRT providers that take insurance is your next stop.
If you never want to inject yourself
You have options. Some clinics give the shot for you, and Aveed is always given in a clinic. There are also non-injection treatment formats like gels and oral capsules. See testosterone injections vs gel for the tradeoffs.
If you plan to have children, discuss fertility before starting
Testosterone from outside the body can lower sperm production. Product labels warn about this, and the Endocrine Society recommends against starting testosterone in men planning fertility in the near term. Changing the injection site does not remove that risk. Talk to a urologist or reproductive urologist first. Our TRT and fertility guide explains the separate options.
Still exploring online programs? Use Find My TRT Path →
Online prescribing note: Under the fourth temporary extension, DEA-registered clinicians may prescribe controlled substances, including testosterone, without a prior in-person visit through December 31, 2026, if the required conditions are met. For testosterone under these flexibilities, that includes an audio-video encounter and compliance with applicable federal and state law. State rules can be stricter, and the federal rule may change after that date.
How did we check this guide?
We read the U.S. prescribing information for the FDA-approved products and exact generic packages in the product table, plus the patient instructions where they exist. We checked federal guidance from the FDA, CDC and National Library of Medicine, and compared provider statements against each company's own pages. This is document research, checked on the dates shown, not a clinical review or a test of anyone's injection technique.
Here's exactly what we did, and didn't do:
- We matched products to labels. For each product, we recorded the labeled method, the named injection area, who gives it, and the label's revision date. We kept a database posting date separate from the label's own revision date, because a new posting doesn't always mean new instructions.
- We checked specific packages. For generics, we checked one Hikma cypionate vial and one Hikma enanthate vial by NDC number. Other manufacturers need their own label.
- We separated facts from claims. Verified label facts, provider-stated claims and our own judgment are labeled differently throughout.
- We didn't publish technique. No needle sizes, angles, depths or doses. Those belong with your care team.
- We didn't test anything. We didn't inject, enroll, inspect a vial, or have this page clinically reviewed.
The FDA requested more testosterone labeling changes in June 2026. A request isn't the same as a finished label, so we'll re-check each product's label and update this page when they change.
We follow How We Review TRT Providers and our editorial standards. If something here is wrong or out of date, tell us and we'll date the correction.
What else should you know about injecting testosterone?
Product instructions and your care team's written plan determine the method, site and schedule. These answers cover questions that general diagrams often leave open.
Where is the best place to inject testosterone?
The best place is the one your product's label and your prescriber specify. The cypionate and enanthate vial labels we checked name the buttock muscle, and Xyosted is labeled for the belly only. If your prescriber chose a different site or method, ask them to confirm that the difference is intentional and explain it in your written plan and training.
Is it better to inject testosterone in the glute or the thigh?
The vial labels name the gluteal (buttock) muscle. The outer thigh is easier to see yourself, and MedlinePlus lists it as an option for IM medicines in general, but using it for testosterone is your prescriber's call. Neither is "better" for everyone.
Can you inject testosterone subcutaneously?
Xyosted is FDA-approved for SubQ use in the belly. Clinicians sometimes prescribe IM-labeled vial products under the skin, which is an off-label use, and limited studies show similar levels to IM. Only do it if your prescriber ordered it.
Can I inject testosterone in my stomach?
Only when your prescriber has specified abdominal SubQ use for your exact product. Xyosted is labeled for the belly only. Xyosted's instructions say to stay at least 2 inches from your navel and avoid tender, bruised, red, scaly or hard skin.
Should I pull back on the plunger before injecting testosterone?
Ask the person who trains you to explain the instructions for your exact product. Advice for vaccine injections does not replace testosterone product instructions. Follow your product-specific training rather than combining steps from different guides.
Can I reuse a needle or syringe?
No. For vial injections, use a new, sterile needle and syringe every time and never share them. Single-use autoinjectors must not be reused either. Reuse can cause infection.
What size needle should I use for testosterone?
Your prescriber and pharmacist choose it based on your product, method and body size. Clinics often supply one needle for drawing medicine from the vial and a different one for injecting. Don't swap needle sizes without asking.
How often should I inject testosterone?
As often as your prescription says, and no more. Schedules vary by product and prescribed plan. Never change your schedule or dose on your own.
Is it normal to have a lump after a testosterone shot?
Small lumps, bruises and redness can happen. In Xyosted's studies, about 1 in 8 men had a site reaction. Contact your care team if a lump, bruise or swelling doesn't go away, or if you get a fever or feel sick.
Can I inject testosterone without a prescription?
No. Testosterone is a Schedule III controlled substance in the U.S. and requires a valid prescription. For adult men being evaluated for testosterone deficiency, the Endocrine Society calls for compatible symptoms or signs plus consistently low testosterone, confirmed with appropriate repeat morning, fasting testing. These criteria do not describe the evaluation for gender-affirming care.
Does changing my injection site protect my fertility?
No. Testosterone can lower sperm production no matter where or how it's injected. If you want children soon, talk to a urologist or reproductive urologist before starting.
Still exploring online TRT options? Use our free Find My TRT Path tool.
Sources
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Pfizer. Depo-Testosterone prescribing information (DailyMed). PI revised September 2025.
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Hikma. Testosterone cypionate injection label (DailyMed). PI revised June 2025.
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Hikma. Testosterone enanthate injection label (DailyMed). PI revised June 2025.
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Antares/Halozyme. Xyosted prescribing information, Medication Guide and Instructions for Use. Revised July 2025.
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Azurity. Azmiro label (DailyMed). Revised July 2025.
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Aveed prescribing information. Revised July 2025.
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Pfizer Medical Information. Testosterone cypionate storage and handling.
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U.S. National Library of Medicine. MedlinePlus: Giving an IM (intramuscular) injection. Reviewed July 23, 2024.
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FDA. Understanding Unapproved Use of Approved Drugs "Off Label".
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FDA. Safely Using Sharps (Needles and Syringes) at Home, at Work and on Travel.
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SafeNeedleDisposal.org — state-by-state sharps disposal rules.
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Figueiredo MG, et al. Testosterone Therapy With Subcutaneous Injections: A Safe, Practical, and Reasonable Option. J Clin Endocrinol Metab. 2022;107(3):614–626.
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Roldán-Chicano MT, et al. Adverse effects of dorsogluteal vs ventrogluteal intramuscular injection: systematic review and meta-analysis. Nursing Open. 2023;10(9):5975–5988.
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Bhasin S, et al. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. 2018.
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Endocrine Society. Testosterone Therapy for Hypogonadism Guideline Resources. 2018 guideline and recommendations.
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DEA/HHS. Fourth Temporary Extension of COVID-19 Telemedicine Flexibilities for Prescription of Controlled Medications. Effective through December 31, 2026.
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ECU Health. How to Give an Intramuscular Injection (video and transcript).
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Male Excel. Testosterone cypionate injections and TRT online. Checked October 29, 2026.
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Hone Health. How much does testosterone cost? (updated September 25, 2026) and How to self-administer testosterone injections (updated February 19, 2026). Checked October 29, 2026.
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FDA. Testosterone Information, including the June 2026 labeling request.
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CalRecycle. Sharps Waste Stewardship, including mail-back options.
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DEA. Drug Scheduling.
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Wilson DM, Kiang TKL, Ensom MHH. Pharmacokinetics, safety, and patient acceptability of subcutaneous versus intramuscular testosterone injection for gender-affirming therapy: A pilot study. Am J Health Syst Pharm. 2018;75(6):351–358.
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Male Excel. FAQ and separate treatment-bundle pricing. Checked October 29, 2026.
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Taurus Meds. $49 test and consultation offer, terms and subscription cancellation/refund policy. Checked October 29, 2026.
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Hone Health. Membership process and pricing. Checked October 29, 2026.
TRT Provider Guide is the independent decision resource for testosterone replacement therapy care. We are not a clinic, pharmacy, laboratory, drug manufacturer, insurer or medical practice. This page is educational information, not medical advice, and it doesn't replace injection training from your care team. Testosterone is a Schedule III controlled substance in the United States and requires a valid prescription. For trouble breathing, facial swelling or chest pain, call 911. A newly painful, swollen, warm or red leg needs prompt medical assessment. Last verified October 2026.
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