Enclomiphene With TRT: Can You Take Both?
Yes, some clinics prescribe enclomiphene with TRT, but no controlled trial we found shows that it protects sperm or testicle size while you stay on testosterone. Enclomiphene's strongest trials tested it instead of testosterone. It is not FDA-approved. If you're trying for a baby now, guidelines recommend against testosterone.
Educational information, not medical advice. Don't start, stop, or change any hormone medicine without your prescriber. Chest pain, trouble breathing, fainting, or sudden vision loss need emergency care. New blurred or double vision, new floaters, or a swollen, painful leg need urgent medical assessment.
That's the short answer. The longer one has a twist. The best "taken together" data we found comes from a company that sells the combination, and it reported no sperm counts. We'll show you exactly what was measured, what wasn't, and what to do next.
Best for: U.S. adult men already on prescribed TRT who have been offered an enclomiphene add-on, or who want to compare that offer with a supervised switch.
Not for you if: you're looking for a self-directed hormone plan. If you're trying to conceive now, start with a reproductive urologist.
What changes the answer for you:
- You're trying to conceive now. Testosterone isn't recommended for men trying to conceive. See a reproductive urologist before you change anything.
- Your LH is high while testosterone remains low. This can suggest a testicular problem and a limited response to enclomiphene. Your clinician should interpret the results alongside your treatment and history.
- You're not on TRT yet and want to protect fertility. Enclomiphene alone, used instead of testosterone, is better studied than the add-on in selected men with secondary hypogonadism. That means low testosterone linked to reduced brain signals; it still needs a clinical evaluation.
- You're done having kids and just hate the shrinkage. Ask your prescriber to assess the change and your options. hCG has more "with TRT" sperm data than enclomiphene, but those studies do not establish how well it preserves testicle size.
Find your situation
The care routes above follow the AUA/ASRM infertility guideline and the study limits below.
TRT Provider Guide is the independent decision resource for testosterone replacement therapy — helping U.S. adults understand how low testosterone is evaluated, compare online and local care models and providers, and choose the next step that fits their health needs, fertility plans, budget, state, and care preferences, with every material claim verified and dated.
Can you take enclomiphene with testosterone?
Answer: Some clinicians prescribe enclomiphene and testosterone together, so the combination is in real use. We found no randomized or controlled trial showing that adding enclomiphene to ongoing TRT protects sperm production, testicle size, or fertility. The strongest enclomiphene studies tested it as a replacement for testosterone, not as an add-on.
Being in use is not the same as being proven.
So if your clinic offered you "TRT plus enclo," you're not crazy for asking questions. It's the right instinct.
Why would a clinic add enclomiphene to TRT?
Usually for one of three reasons:
- Fertility. They hope it keeps sperm production going while you take testosterone.
- Testicle size. Testosterone often makes testicles shrink. They hope enclomiphene limits that.
- "Keeping the system online." Some clinics want your own hormone signals to stay active in case you stop TRT later.
Those are reasonable goals. The problem is the evidence behind this particular tool for those goals, and we'll get to that.
How the two medicines work (the "two brakes" idea)
Your brain controls testosterone with two signal hormones:
- LH (luteinizing hormone) tells your testes to make testosterone.
- FSH (follicle-stimulating hormone) helps your testes make sperm.
When you take testosterone from outside your body (that's what TRT is), your brain senses plenty of it and turns those signals down. Less LH and FSH means your testes make less of their own testosterone and fewer sperm. That's why testicles often shrink on TRT.
One way to picture this feedback is with two "brakes":
- The testosterone brake. Your brain senses testosterone directly.
- The estrogen brake. Some testosterone turns into estradiol, a form of estrogen, and your brain senses that too.
Enclomiphene is a SERM (selective estrogen receptor modulator). It blocks estrogen's signal in the brain. That releases the estrogen brake, and LH and FSH can rise.
Here's the catch. Enclomiphene blocks estrogen feedback; it doesn't directly block testosterone's androgen signal. The two-brakes picture is a simplification: LH and FSH are not controlled in exactly the same way. Human research found both direct and estrogen-mediated feedback on LH, while testosterone's effect on FSH was mainly through conversion to estrogen. Mechanism study
When you're not on TRT, blocking estrogen feedback can raise testosterone in selected men. When you are on TRT, that mechanism alone cannot tell you whether an add-on will preserve sperm or testicle size. Your testosterone format matters, and those outcomes have not been established in the combination reports below.
The right TRT provider is not the same for every person — it depends on whether low testosterone has been properly evaluated, your symptoms and health history, your fertility plans, your state, your insurance or cash-pay preference, your treatment-format preference, your budget, and whether online or in-person care is the better starting point. Some situations belong with primary care, urology, endocrinology, reproductive urology, or urgent or emergency care when the symptoms warrant it. Because a general answer cannot resolve those for you, use TRT Provider Guide's Find My TRT Path tool to map your situation to the right care route and the questions to ask before you pay.
Find My TRT Path is educational. It doesn't diagnose low testosterone, decide medical eligibility, or guarantee a prescription.
What do studies on enclomiphene with TRT actually show?
Answer: The randomized enclomiphene trials compared it against testosterone as separate treatments and found that enclomiphene raised testosterone from baseline while maintaining sperm measures on average. Reports of men taking both medicines together do exist. The two we found were run by a company that sells the combination; they reported blood hormones, and one also used symptom surveys, but neither reported sperm outcomes.
We reviewed the relevant human reports we found and sorted them by one question: did people actually take both medicines at the same time? That one question changes how much each study means for you.
What was actually tested?
Checked October 23, 2026. "Together" means enclomiphene and testosterone taken at the same time; the two hCG rows are labeled separately for comparison.
What this table tells you
1. The good enclomiphene trials answer a different question. They show enclomiphene can raise testosterone and maintain sperm measures instead of TRT in selected men. They say nothing about stacking it with TRT.
2. The "together" data is thinner than it sounds. Both enclomiphene-plus-testosterone reports come from one company that sells the combo. Neither reported semen or pregnancy outcomes. Hormone levels are a clue, not proof of fertility. (We explain why in the next section.)
3. It didn't maintain hormone signals at every dose. In the cream report, the lowest enclomiphene dose didn't stop LH and FSH from crashing. So keeping those signals up isn't automatic. It depends on the details, and those details belong with your prescriber, not a forum post.
4. It may raise estrogen. In the same cream report, estradiol climbed about 54% in the higher-dose observations. That report cannot show how much of the change came from adding enclomiphene. That's not necessarily dangerous. Ask whether estradiol testing fits your symptoms and treatment.
5. hCG has actual "with TRT" sperm data. It's still small and imperfect, and the newer study used hCG plus FSH. The enclomiphene-plus-TRT reports we reviewed did not report sperm outcomes.
What would settle the question?
A fair test would give the same testosterone treatment to two groups, add enclomiphene to only one, follow them for months, and count sperm and pregnancies. We did not find that study in the published literature. Until it is, any page promising that enclomiphene "protects your fertility on TRT" is going further than the evidence. That includes provider pages.
Watch for these red flags:
- A claim that a meta-analysis proves enclomiphene plus TRT improves sperm. The 2025 meta-analysis compared SERMs with testosterone gel or placebo as separate treatments, not SERMs plus testosterone.
- A promise of no impact on fertility. Trials showed sperm counts were maintained on average. That's encouraging, but it isn't a promise for every man.
- Calling enclomiphene natural TRT. Enclomiphene isn't testosterone replacement. It's a different drug with a different job.
Does enclomiphene preserve fertility while you're on TRT?
Answer: That hasn't been shown. A blood test showing normal LH and FSH doesn't prove you're making sperm, and a normal sperm count doesn't guarantee a pregnancy. If having children soon matters to you, current guidelines recommend against testosterone; talk with a reproductive urologist before changing your plan. AUA/ASRM
Blood tests, sperm tests, and pregnancy answer different questions
This is where a lot of people get misled, so here's the simple version:
The enclomiphene-plus-testosterone reports we reviewed did not report semen or pregnancy outcomes. FDA reviewers made the same point about enclomiphene in general. In its 2022 review, FDA cited its 2018 guidance for treatments of nonstructural hypogonadotropic hypogonadism: improved semen measures alone do not establish a fertility benefit. That guidance concerns low testosterone linked to reduced brain signals without a structural disorder. FDA review
What the guidelines say
- AUA (American Urological Association), testosterone guideline: Exogenous testosterone "should not be prescribed to men who are currently trying to conceive." That's a strong recommendation with the highest evidence grade (Grade A).
- AUA and ASRM male infertility guideline (2024): For a man interested in current or future fertility, clinicians should not prescribe exogenous testosterone—testosterone supplied from outside the body.
- Same guideline: SERMs, hCG, aromatase inhibitors, or combinations of these medicines may be used in infertile men with low testosterone. That's a conditional recommendation with low-certainty evidence (Grade C). It is a drug-class statement, not an endorsement of enclomiphene added to TRT.
- AUA, on SERMs: If testosterone remains low and LH is high after starting a SERM, that can indicate testicular dysfunction and a limited testosterone response.
- Endocrine Society: Recommends against starting testosterone in men planning fertility in the near term.
Notice what's missing. The guidelines reviewed here do not recommend adding enclomiphene to ongoing TRT as a way to protect fertility.
The AUA/ASRM discussion says evidence for preserving sperm production by adding hCG alone or combinations involving hCG, SERMs, or FSH to testosterone is too limited to recommend the approach. It distinguishes near-term plans from possible paternity farther in the future; in the latter situation, testosterone may be considered with counseling about sperm suppression and recovery. AUA/ASRM
If you stop TRT, does fertility come back?
Usually, but not always, and not always fast. In an analysis of 1,549 healthy men in hormonal male-contraception studies, the estimated chance of returning to a sperm concentration of 20 million/mL was 67% within 6 months. Some took up to 2 years. Those results do not predict recovery after long-term TRT in men with low testosterone. Lower starting sperm counts were linked with slower recovery in that analysis, and current guidelines caution that some men never fully recover sperm production after testosterone therapy. That's why the timing of your family plans matters more than any add-on. Recovery study · AUA/ASRM
If children are part of your plan
Bring these three things to a urologist or reproductive urologist:
- Your timeline (trying now, within a year, or someday).
- Whether a semen analysis makes sense before you change anything.
- Your full medication list, including exact product names.
If you want kids in the next year or two, start there, not with an online add-on. If you're still not sure which kind of doctor fits your situation, Find My TRT Path can lay out the care routes and the questions to ask each one.
Enclomiphene vs hCG on TRT: which add-on has better evidence?
Answer: If you're staying on testosterone, hCG has more direct sperm data than enclomiphene, but current guidelines consider the add-on evidence too limited to recommend it for preserving fertility. It acts like LH right at the testes and can stimulate testosterone production even when TRT suppresses the brain's LH signal. Enclomiphene is better studied when it replaces testosterone. hCG mechanism study · AUA/ASRM
Each option has trade-offs in approval status, form, and how well it's been studied. hCG means human chorionic gonadotropin; it is not testosterone replacement.
The approval distinction comes from the Pregnyl prescribing information and FDA enclomiphene review.
When might a clinician still choose enclomiphene with TRT?
There can be practical reasons: you can't stand extra injections, hCG is hard to get or costs too much in your situation, or your prescriber is considering a change from testosterone to another treatment. Those are reasonable conversations to have. Just ask two questions: what result will we measure, and when? If nobody can answer that, you're paying for a guess.
Other options worth asking about
Shorter-acting testosterone, like nasal testosterone and some oral products, seems to suppress LH and FSH less than long-acting injections in early studies. Those observations do not establish fertility protection or how an enclomiphene add-on performs across products. The data on sperm is still limited, and the AUA doesn't recommend nasal testosterone for men who want current or future fertility. Nasal study · Oral testosterone analysis (abstract) · AUA/ASRM
Read more in our Natesto reviews and oral testosterone versus injections guide.
Leaning toward hCG? Bring the comparison above to your prescriber, then use our guide to TRT and fertility to prepare for that conversation.
Does it matter if you use injections, cream, or oral testosterone?
Answer: Yes—a report about one testosterone format doesn't prove the same result for another. The combination reports we found used oral native testosterone or testosterone cream, not ongoing injections. Results from those products do not establish what happens with injections, gels, or FDA-approved oral testosterone undecanoate products.
Here's how the "together" evidence lines up by format:
Bottom line: If you're on injections, we found no direct clinical-outcome data on adding enclomiphene. Ask your prescriber what evidence matches your exact product. For a broader comparison of formats, see enclomiphene vs testosterone injections.
Is enclomiphene FDA-approved, and is it the same as Clomid?
Answer: No to both: there is no FDA-approved product with enclomiphene as its active ingredient, and Clomid (clomiphene) contains two forms, called isomers—enclomiphene and zuclomiphene. U.S. clinics offer enclomiphene through compounded prescriptions, subject to applicable requirements. Compounded medicines don't go through FDA review for safety, effectiveness, or quality before you get them. FDA review · Clomiphene label · Compounding risks
Quick status check
Checked October 2026.
How enclomiphene got here
- 2015: The company developing enclomiphene reported receiving a "complete response letter" from the FDA, which meant the application was not approved. FDA considered the phase III study design inadequate to demonstrate clinical benefit and recommended additional phase III studies. FDA review
- 2018: The European Medicines Agency's scientific committee recommended refusing EnCyzix, an enclomiphene product. European marketing authorization was refused that year because clinical benefit had not been established and safety concerns included blood clots. EMA assessment
- 2022: FDA reviewers recommended against adding enclomiphene to the 503A bulk-substances list, citing safety concerns and unproven clinical benefit. That recommendation was not a final compounding ban. FDA review
- Current status, checked October 23, 2026: FDA's list updated May 14, 2026 still places enclomiphene in Category 1, meaning it is under evaluation. FDA's interim policy says it does not intend to take enforcement action over this bulk-substance requirement when the policy's conditions are met. This is not FDA approval or blanket permission to compound; other federal and state requirements still apply. It could change. FDA list · Interim policy
Why that matters to you
"Off-label" and "unapproved" aren't the same thing. Clomiphene is an approved drug used off-label in men. There is no FDA-approved enclomiphene product. Whether a particular compounded prescription meets applicable requirements depends on the product, compounder, prescriber, and state. FDA has not verified the finished compounded product's safety, effectiveness, or quality before marketing. Ask which pharmacy makes yours. FDA policy · Compounding risks
Avoid any enclomiphene sold online as "for research use only" or "not for human consumption." That's not a prescription medicine.
Testosterone is a controlled substance
Testosterone is Schedule III in the U.S. and always needs a valid prescription. Through December 31, 2026, the federal temporary extension allows DEA-registered clinicians to prescribe it after a qualifying live audio-video telemedicine visit without a prior in-person evaluation, provided the prescription meets other federal and state requirements. State rules and individual prescribers can still require one. We'll update this page when that rule changes. Testosterone label · DEA extension More on enclomiphene itself: enclomiphene vs clomiphene.
What are the risks of taking enclomiphene with TRT?
Answer: Events reported in enclomiphene trials include headache, hot flashes, nausea, muscle spasms, and visual symptoms; regulators also raised concerns about blood clots. The reports reviewed here do not establish the long-term safety of taking enclomiphene with TRT. Your prescriber should weigh your history and plan your follow-up labs. FDA review · EMA assessment
What regulators flagged
From the FDA's 2022 review and EMA assessment of enclomiphene's clinical trials:
- Most frequently reported adverse events: headache, hot flashes, nausea, and muscle spasms.
- Most common reasons people quit the trials: blurred vision, muscle spasms, headache, and aggression.
- Blood clots: Europe's regulator counted 4 blood-clot events in enclomiphene trial patients, one of them fatal, and none in the testosterone or placebo groups. It said the cause wasn't clear. These reports do not establish the size of any drug-related risk.
- Other signals: heart-rhythm events, higher estradiol, higher PSA (prostate-specific antigen, a prostate blood marker), and higher hematocrit (the share of your blood made of red blood cells).
These reports came from studies of enclomiphene without concurrent TRT. Testosterone carries its own known risks, including higher hematocrit and higher blood pressure. Taking both may expose a patient to risks from each medicine, but the evidence reviewed here does not establish how those risks change when the medicines are used together over years. Testosterone label · FDA labeling update
Who should be extra careful
Tell your prescriber about past blood clots, vision problems, abnormal blood counts, and liver or kidney disease. FDA's review identified clotting and blood-count concerns and incomplete information about how liver or kidney impairment affects enclomiphene exposure. There is no FDA-approved enclomiphene label with a standard contraindication list. If you have a cancer history, your clinician also needs to review whether your testosterone treatment is appropriate. FDA review · Testosterone label
Get help fast if you notice
- New blurred or double vision, or floaters. Contact your prescriber or a doctor urgently. Sudden vision loss is an emergency.
- Chest pain, trouble breathing, or fainting. Call 911.
- A painful, swollen, warm leg. Seek care the same day.
These symptoms need assessment whether or not a hormone medicine caused them. CDC clot guidance · Vision guidance · New floaters guidance
What monitoring should cover
There's no one-size schedule. Ask your prescriber how they'll track:
- Testosterone, LH, and FSH, to assess the hormone response
- Estradiol, when appropriate for your symptoms and treatment
- Hematocrit and blood pressure
- PSA, when appropriate for your age and history
- A semen analysis, if fertility is the reason you're taking it
For a deeper look, see our review of enclomiphene side effects.
Should you switch from TRT to enclomiphene instead?
Answer: For selected men with secondary hypogonadism, a supervised switch may be an option. The strongest trials tested enclomiphene instead of testosterone; a small trial specifically studied men previously on testosterone gel. A switch should be planned with your prescriber because hormone levels and symptoms can change. Switching trial · AUA/ASRM
A functioning pituitary and responsive testes matter, and low LH while you're taking TRT does not establish that enclomiphene is a good fit. The pituitary is the small gland below the brain that releases LH and FSH.
Low testosterone should be diagnosed from symptoms or signs plus consistently low results, with repeat early-morning testing; the Endocrine Society specifies morning fasting measurements. A symptom quiz, one result, or 300 ng/dL alone does not establish the diagnosis. If you're already taking hormones, your clinician needs your original records and a plan for interpreting current tests. Endocrine Society · AUA
This might fit you if
- Your low testosterone was confirmed with symptoms plus repeat early-morning blood tests.
- Your clinician has reviewed your pretreatment hormone results and the cause of low testosterone.
- Fertility matters to you now or soon, and a clinician is assessing which treatment fits that goal.
- You're comfortable with a medicine that isn't FDA-approved and is made by a compounding pharmacy.
Get specialist advice first if
- You were told you have primary hypogonadism (the testes themselves aren't working well). Ask your clinician how that diagnosis affects your options and fertility plans. Our enclomiphene vs TRT guide covers this in detail.
- You're trying to conceive now. Start with a reproductive urologist, not an online switch.
- You have a history of blood clots or vision problems.
What to expect
The best switching data is small but real. In Kaminetsky 2013, men moved from testosterone gel to enclomiphene ended up with similar testosterone levels after 6 months, higher LH and FSH, and higher sperm counts than men assigned to testosterone gel. Two of the six men assessed on enclomiphene at 6 months never exceeded 300 ng/dL at the 3- or 6-month visits, so it doesn't work for everyone. That was a study threshold, not a universal diagnosis. Original report
Your hormone levels and symptoms may change during a switch. Don't stop TRT on your own to "test" this. Your prescriber should plan the timing and the follow-up labs. Our guide on stopping TRT explains what that process usually involves.
Ready to explore the switch?
If this sounds like you, ask a clinic that offers both TRT and an enclomiphene-based option whether it can evaluate and supervise a change in treatment. Having both options on its website doesn't guarantee that either will be appropriate or available for you.
Affiliate disclosure: TRT Provider Guide has commercial relationships with Male Excel, Hone Health, and Taurus Meds for certain offers. The provider links on this page lead to public information, not paid enrollment offers. Commissions don't change our evidence, our cost math, or who we tell to go elsewhere. Read our affiliate disclosure.
→ Review Male Excel's Triclozene description — its $99 home-test and consult offer is published, but its ingredient descriptions conflict with its pricing page. Confirm the formula before paying for treatment.
→ See Hone Health's enclomiphene plan and membership pricing — enclomiphene tablets, with TRT also listed among its treatment options; any switch needs a clinician's assessment.
Where can you get enclomiphene online, and what does year one cost?
Answer: Hone Health, Hims, and Taurus Meds publish enclomiphene offers; Male Excel markets Triclozene, but its ingredient descriptions conflict. Hone Plus's published starting prices total $2,169 for 12 advertised months, while other offers have price or billing gaps that prevent a complete comparison. These are prescription-evaluation routes, not verified offers to add enclomiphene to your current TRT.
What we actually verified
Year-one cost at a glance
These are starting-price scenarios for 12 advertised months, assuming unchanged prices and an eligible prescription. They are not complete checkout quotes or guaranteed 365-day supplies. The table keeps medication, membership, initial testing, and unresolved charges separate.
Sources: Male Excel product and pricing; Hone Plus, Premium, product, and supply explanation; Hims offer, membership, and terms; Taurus product and terms.
Prices are what each provider published on the date checked. Your dose and plan can change the total. Enclomiphene is not FDA-approved; neither a blend nor a provider's separate FDA-approved testosterone offering changes that.
What is still missing from a full first-year quote? Add any required confirmation test, extra visits, medicine changes, shipping, taxes, and every refill needed to cover 365 days. A 28-, 30-, or 60-day supply does not divide neatly into 12 calendar months. Ask for the total first charge and the renewal dates, not just a monthly equivalent.
Hone's plan pages list TRT confirmation at $45 in-lab or $80 at home for Plus, and $25 in-lab for Premium. Its separate retesting page also says clinically necessary retesting is free, so confirm which policy applies to your evaluation. If the listed confirmation fee applies, the corresponding starting scenarios become $2,214 or $2,249 for Plus, and $2,466 for Premium using the $43 medicine price. Plus confirmation fees · Premium confirmation fee · Plan FAQ · Retesting policy
For Taurus, $1,837 + (12 × $17.99) would equal $2,052.88 only if that fee is additional and monthly. The terms say “per billing period,” so that is a conditional example, not a verified annual quote.
An enclomiphene add-on needs an individual quote. Hone's standalone medication listing does not establish that it will prescribe enclomiphene with your existing TRT. Ask whether the plan is offered, whether your current membership covers it, and which additional medication or tests would be billed.
Male Excel: confirm the Triclozene formula before paying
Male Excel describes its service as physician-led, with in-house providers, 60-day check-ins, and lab testing every 6 months built into its $99 membership. It lists TRT injections, testosterone cream, and Triclozene. Ask whether its clinician can evaluate and supervise a change between treatments in your case. Its TRT page says that when fertility is a priority, providers may recommend supportive treatments such as enclomiphene. It doesn't say whether that means alongside testosterone or instead of it, so ask. Male Excel TRT page
The honest trade-off: The pages we reviewed market Triclozene rather than an enclomiphene-only product, but disagree about its formula. The product page describes enclomiphene with two unnamed thyroid-supporting ingredients. The pricing page instead names clomiphene, thyroid, and selenomethionine. Those descriptions are not interchangeable. Obtain the full ingredient list from the prescriber and dispensing pharmacy before deciding whether it fits your needs. Product page · Pricing page
Male Excel builds its model around managing testosterone, thyroid, and estrogen together. That is its stated care model, not proof that you need all three addressed with medicine. Before you start, ask whether your thyroid labs actually call for any thyroid medicine in the proposed prescription.
Best for researching: men who want to discuss several hormone-treatment options through one clinic and are willing to resolve the formula and full quote first.
Not for you if: you need a verified enclomiphene-only offer; the reviewed pages don't establish one. If you're trying to conceive now, start with reproductive urology.
→ Compare Male Excel's published Triclozene prices
Hone Health: enclomiphene by itself, with TRT also listed
Hone lists plain enclomiphene tablets in 12.5 mg and 25 mg strengths, prescribed by physicians at Hone-affiliated practices. Its help center says enclomiphene isn't recommended for men with elevated LH. Its published Plus and Premium initial lab panels include LH; the result still needs clinical interpretation. Hone also offers TRT, although any switch depends on the clinician's assessment and your eligibility. Medication help · Plus · Premium
The $42 isn't the real monthly price. Enclomiphene is sold on top of a membership: Plus starts at $177 per month ($135 + $42), while Premium's current plan table starts at $198 ($155 + $43). The separate product page still says medication starts at $42. Confirm the price attached to your prescription.
Best for researching: men who want enclomiphene alone and a published medication-plus-membership price, with TRT also offered by the service.
Not for you if: you're choosing solely on the medication price without checking membership, testing, and refill terms. Men trying to conceive now should start with reproductive urology.
→ Check Hone's current membership options and enclomiphene pricing
Hims: medication and membership are billed separately
Hims lists Testosterone Rx+ from $49 per month for medication, with required membership billed separately. It now also lists injectable and oral TRT as separate treatments. Hims isn't available in all 50 states for testosterone treatment, and it says this treatment is not eligible for FSA or HSA reimbursement. Confirm the membership cadence, medication renewal amount, and cancellation terms before comparing costs. Current offer · Membership explanation
Taurus Meds: confirm the offer and additional fees
Taurus publishes both TRT and an enclomiphene product listing. Its enclomiphene page advertises $149 per month after a $49 test and review, while its homepage promotes a free test. Its terms also list a recurring membership fee. Confirm which offer and fees apply before paying. A general claim about access to FDA-approved medicines does not make enclomiphene FDA-approved. Product page · Homepage · Terms
→ Review Taurus Meds' enclomiphene price and listed inclusions
What should you check about state access, cancellation, and your records?
An advertised treatment is not confirmation that a clinician can prescribe that exact product in your state. A paid assessment also does not guarantee a prescription. These are published policies, not service-quality tests.
Sources: Male Excel availability, terms, and consent; Hone state directory, outside-pharmacy policy, cancellation, consult export, and lab access; Hims terms and records policy; Taurus terms and privacy policy.
Before paying, ask who will treat you, which state license they hold, which pharmacy will dispense the exact formula, and how repeat early-morning testing is handled. We did not verify a patient-specific clinician or pharmacy license. Routine follow-up labs do not establish that two diagnostic morning tests are included, and a hormone panel is not a semen analysis.
Support also means different things. Male Excel advertises provider access; Hone describes secure messaging rather than live chat; Hims lists provider messaging; Taurus advertises 24/7 support. None of those claims establishes an immediate clinician response. Ask who handles a side effect, how quickly, and where to go when the service is unavailable. Male Excel · Hone contact policy · Hims terms · Taurus
A local urologist or reproductive urologist: best when fertility is near-term or insurance matters
A urologist can evaluate fertility and discuss testing and treatment options. Ask the practice which medicines it prescribes and whether your visits, tests, and prescriptions are covered by your insurance. If children are part of your next two years, this is the right first stop. That is a practical planning window, not a guideline cutoff or a promise about recovery time.
What are the 10 questions to ask before adding enclomiphene to TRT?
Answer: Before you pay for enclomiphene on top of TRT, ask what problem it's meant to solve, what evidence applies to your exact situation, and how you'll both know it's working. Ask for the full added cost too. These ten questions turn every gap on this page into something you can bring to your appointment.
- What exactly is enclomiphene supposed to do for me while I stay on testosterone?
- Have you reviewed my pretreatment LH and FSH and the cause of my low testosterone? How does my current treatment affect those results?
- Which study tested enclomiphene with my testosterone product and format?
- Did that study measure sperm or pregnancy, or only blood hormones?
- Given my plans for children, should I get a semen analysis or see a reproductive urologist first?
- Would hCG, or switching off TRT, fit my goal better?
- Is my prescription plain enclomiphene or a blend? Which compounding pharmacy makes it?
- Which labs will you check, how often, and who reviews them?
- Which side effects should make me call you, and which mean urgent care?
- What's the total added cost over the first year, including medicine, membership, labs, and shipping?
Screenshot or print this list and bring it to your visit. Write down the answers and the date.
How did we check this page?
Answer: We followed How We Review TRT Providers, separating verified facts, provider-stated claims, customer-experience signals, and our own editorial conclusions. We read the original studies, FDA and guideline documents, and each provider's current pages. This is a targeted editorial review, not a systematic review or medical advice for your care.
Every price and policy is dated. No customer testimonials or firsthand product claims are used on this page.
Our method, How We Review TRT Providers, looks at clinical eligibility, testing, clinician access, state availability, treatment formats, medication and pharmacy transparency, fertility handling, monitoring, total cost, cancellation, support, and how honest each provider's claims are. We include published mandatory charges in our cost scenarios and identify costs or billing terms we could not verify.
For this page, we:
- Sorted the relevant human reports we found by one question: were both medicines taken at the same time?
- Recorded what each study measured: blood hormones, sperm, symptoms, or pregnancy.
- Read FDA's 2022 enclomiphene review, the FDA compounding list dated May 14, 2026, and the AUA and AUA/ASRM guidelines directly.
- Pulled prices and policies from provider pages and did the year-one math ourselves.
Limits: We found no controlled trial of enclomiphene added to ongoing TRT, but our search wasn't a formal systematic review. If a real combination trial is published, we'll update this page and the table above.
Read our editorial standards and corrections process and privacy policy.
Enclomiphene with TRT: what else do readers ask?
Answer: The main questions are whether the combination preserves sperm, limits shrinkage, or offers a better route than a supervised switch. The evidence differs for each goal, and normal hormone signals do not settle the fertility question.
Can you take enclomiphene and testosterone at the same time?
Some clinicians prescribe both. We found no controlled trial showing that the combination protects fertility or testicle size. The enclomiphene-plus-testosterone reports we reviewed measured blood hormones, with symptom surveys in one, but did not report sperm outcomes.
Does enclomiphene stop testicular shrinkage on TRT?
It hasn't been proven. Enclomiphene alone increased hormone signals and maintained sperm measures on average in trials. On top of TRT, the reports we found did not report testicle-size measurements. hCG has more direct sperm data with TRT, but those studies do not establish how well it preserves size.
Will enclomiphene keep me fertile while I'm on TRT?
Nobody can promise that. If you want children soon, guidelines say testosterone isn't the right treatment. A reproductive urologist can check your sperm and lay out your options.
Is enclomiphene better than hCG on TRT?
For men staying on testosterone, hCG has more direct sperm data, but current guidelines consider the evidence too limited to recommend add-ons for preserving fertility. Enclomiphene is better studied as a replacement for TRT. See the comparison table above and our TRT and fertility guide.
If my LH and FSH are normal on the combination, am I fertile?
Not necessarily. Those are signals from your brain, not a sperm count. A semen analysis is the test that looks at sperm, and even that can't guarantee a pregnancy.
Is enclomiphene FDA-approved?
No. There's no FDA-approved product with enclomiphene as its active ingredient. Clinics offer compounded prescriptions, subject to applicable requirements.
Is enclomiphene the same as Clomid?
No. Clomid (clomiphene) contains two isomers: enclomiphene and zuclomiphene. A standalone enclomiphene prescription contains the enclomiphene isomer rather than that mixture; a compounded blend may contain other ingredients.
Can I switch from TRT to enclomiphene?
It may be an option for selected men with secondary hypogonadism. Your clinician should review the original diagnosis; low LH during TRT is not enough to decide. Plan any switch with your prescriber.
Does adding enclomiphene raise estrogen?
Estradiol rose about 54% in the higher-dose observations in one company-run report of testosterone cream plus enclomiphene. The uncontrolled report cannot show how much of that change was caused by adding enclomiphene. Ask your prescriber whether estradiol testing is appropriate for your symptoms and treatment.
How much does enclomiphene cost online?
Using published starting prices checked October 23, 2026, Hone Plus works out to $2,169 for 12 advertised months, and Premium to $2,441 using its current plan table, before any additional costs. Male Excel's $2,427 scenario excludes shipping and sits alongside a conflicting price. Hims and Taurus have unresolved billing details. The cost table shows the calculations and exclusions.
Still not sure which TRT care route fits you? Use our free Find My TRT Path tool.
Sources
All sources checked October 23, 2026.
Guidelines and regulators
- American Urological Association. Evaluation and Management of Testosterone Deficiency guideline. Published 2018; reviewed and validity confirmed 2024. Statement 23, SERM discussion, and Table 7.
- AUA/ASRM. Diagnosis and Treatment of Infertility in Men (2020; amended 2024). Statements 40–42 and accompanying discussion.
- Endocrine Society. Testosterone Therapy for Hypogonadism guideline (Bhasin et al., 2018).
- U.S. FDA. Pharmacy Compounding Advisory Committee briefing, June 8, 2022 — Evaluation of Enclomiphene Citrate.
- U.S. FDA. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A, updated May 14, 2026, and January 2025 interim policy.
- U.S. FDA. Understanding the Risks of Compounded Drugs.
- European Medicines Agency. EnCyzix assessment report, 2018.
- DEA/HHS. Fourth temporary extension of telemedicine flexibilities through December 31, 2026.
- DailyMed prescribing information: clomiphene, Pregnyl, and testosterone cypionate.
- U.S. FDA. Class-wide testosterone labeling changes, February 28, 2025.
- CDC. About Blood Clots. NHS. Vision loss and floaters and flashes.
Studies and reviews
- Hochu G, Geyer-Kim I, Kim E. Preserving spermatogenesis in testosterone deficiency. Transl Androl Urol. 2025;14(12):3975–3987. Background review; primary studies and guidelines are cited directly above.
- Kaminetsky J, et al. Oral enclomiphene citrate: comparison with testosterone gel. J Sex Med. 2013.
- Wiehle RD, et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia. Fertil Steril. 2014.
- Kim ED, et al. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone. BJU Int. 2016.
- Hsieh TC, et al. Concomitant hCG and TRT: retrospective semen and pregnancy observations. J Urol. 2013;189:647–650.
- Stocks BT, et al. Restoration of sperm production after testosterone therapy using hCG and FSH. Fertil Steril. 2025;123:607–615.
- Liu PY, et al. Sperm recovery after hormonal male contraception. Lancet. 2006;367:1412–1420.
- Hayes FJ, et al. Differential regulation of gonadotropin secretion by testosterone in the human male. J Clin Endocrinol Metab. 2001.
- Coviello AD, et al. hCG and testosterone inside the testes during testosterone-induced hormone suppression. J Clin Endocrinol Metab. 2005.
- Ramasamy R, et al. Nasal testosterone and semen measures: a single-arm trial. J Urol. 2020.
- Kavoussi P, et al. Oral testosterone undecanoate and gonadotropins: post hoc phase III analysis. Conference abstract. J Sex Med. 2021;18(Suppl 1):S18–S19.
- Hohl A, et al. Clomiphene or enclomiphene citrate for male hypogonadism: systematic review and meta-analysis. 2025.
Provider-published reports (company-run; not independent)
- Maximus. Oral Testosterone and Enclomiphene white paper.
- Maximus. Topical Testosterone with Enclomiphene report.
Provider pages used for pricing and policies
- Male Excel: Triclozene, pricing, TRT online, availability, terms, and informed consent.
- Hone Health: enclomiphene, medication details, Plus, Premium, membership FAQ, retesting, supply length, state availability, cancellation, outside pharmacy, consult records, lab results, and support.
- Hims: testosterone treatment offers, membership, terms, and medical records.
- Taurus Meds: enclomiphene, homepage offer, terms, and privacy/records policy.